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Does anyone have the link to download the Becker’s CPA Exam Review software for DESKTOP I’ve been searching and could only find the mobile app. Why is that? One reason is that all the top 100 accounting firms, including the Big 4, use this program to help their employees pass the exam. CAN YOU DOWNLOAD BECKER CPA REVIEW TO COMPUTER SOFTWARE CAN YOU DOWNLOAD BECKER CPA REVIEW TO COMPUTER FULLĭashboard & Course Software/Layout The Becker CPA Review course is designed in such a way that it’s very easy to navigate the full course thanks to the Adapt2U learning technology. Over 2,000 firms, government bodies, universities, and other organizations use Becker, and they trust its ability to prepare students for a career in public accounting. You can actually leverage the fact that you’ve trained with Becker to land a great job! Remember, Becker frequently offers discount codes on their courses as well.
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The problem then, and now, is to determine the dose threshold for toxicity in order to tailor therapy optimally. 9 This elegant chemistry explains why at standard doses paracetamol remains one of the safest drugs used in clinical practice, but that with increasing dose hepatic toxicity becomes more likely. 6–8 The important finding was that toxicity was glutathione dependant. Animal experiments clearly demonstrated that the hepatic toxicity of some molecules was by metabolism which could be both induced and inhibited, and that it involved production of reactive intermediates in metabolism that were normally neutralised by glutathione. The breakthrough came in the early 1970s with the development of the concept that free radical generation during drug metabolism was a potential cause of toxicity. The major clinical presentation was of hepatic failure due to acute liver necrosis. 4,5 At that time the biochemical mechanisms underlying paracetamol toxicity were unknown, and thus treatment was entirely symptomatic. The first documented cases of organ toxicity from paracetamol were in Scotland in 1966. 3 The precise psychosocial factors behind this increase are unclear, but by the early 1970s admissions to hospital from patients deliberately ingesting aspirin and paracetamol had become a regular, problematic medical emergency. The profile of the epidemiology of poisoning changed over the next 40 years with poisoning becoming a common reason for emergency admission to hospital. 1,2 At that time presentations with poisoning, either accidental or from self-harm, were unusual in Europe. Introduction Paracetamol was introduced into clinical medicine in the 1950s as an antipyretic analgesic. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future. This article examines the history of the development of NAC and recent developments in its use. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. Paracetamol poisoning was first reported in 1966. |